Fig 1: Lung complement proteins, IL-8 and RANTES, in MERS-CoV-infected patients. Patients were divided into non-survival (n = 22) and survival (n = 9) groups. (A) The concentration of C3a was elevated in the non-survival group compared with that in the survival group (P < 0.0024). (B) Complement C5a was higher in the non-survival group compared with that in the survival group (P < 0.0001). (C) The levels of factor P were significantly elevated in the non-survival group compared with that in the survival group (P < 0.0001). (D) The levels of C4BP were significantly elevated in the survival group compared with that in the non-survival group (P < 0.0113). (E) The concentration of IL-8 was significantly higher in the non-survival group compared with that in the survival group (P < 0.0001). (F) The levels of RANTES were significantly elevated in the non-survival group compared with that in the survival group (P < 0.0001)
Fig 2: Lung complement proteins, IL-8 and RANTES, in MERS-CoV-infected patients and MERS-CoV non-infected group. (A) The concentration of C3a was significantly higher in MERS-CoV-infected patients compared with that in the MERS-CoV non-infected group (P < 0.0001). (B) Complement C5a was significantly higher in the MERS-CoV-infected patients compared with that in the MERS-CoV non-infected group (P < 0.0001). (C) The levels of factor P were significantly elevated in the MERS-CoV-infected patients compared with that in the MERS-CoV non-infected group (P < 0.0001). (D) The levels of factor H were elevated in the MERS-CoV-infected patients compared with that in the MERS-CoV non-infected group (P < 0.0236). (E) Complement factor I was elevated in the MERS-CoV-infected patients compared with that in the MERS-CoV non-infected group (P < 0.0065). (F) There was no statistical significance (ns) in the lung concentrations of C4BP in MERS-CoV-infected patients compared with that in the MERS-CoV non-infected group. (G) The levels of C1q were significantly elevated in the MERS-CoV-infected patients compared with that in the MERS-CoV non-infected group (P < 0.0001). (H) The concentrations of IL-8 were significantly higher in the MERS-CoV-infected patients compared with that in the MERS-CoV non-infected group (P < 0.0001). (I) The levels of RANTES were significantly elevated in the MERS-CoV-infected patients compared with that in the MERS-CoV non-infected group (P < 0.0001). The healthy group in the figures refers to MERS-CoV non-infected group
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