Mouse Atrial Natriuretic Peptide/ANP ELISA Kit (Colorimetric) NBP2-66733 from Novus Biologicals, a Bio-Techne Brand

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PloS one
January 01 2022

Fig 1: Cardiac hypertrophy in mice with cardiac deletion of Prdm16.(A) Shapes of whole hearts from 5-month-old female mice. (B) Body weight, (C) heart weight, and (D) heart-to-body weight ratio. (E) ANP levels in left ventricle and (F) plasma. Error bars, mean ± SEM; number (N), number of mice; statistical significance by student’s t-test, a (P < 0.05), b (P < 0.01), and c (P < 0.005).
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PloS one
January 01 2022

Fig 2: Altered transcriptional profiles in mouse hearts with a Prdm16 deletion and analysis of functional pathways.RNA-seq analysis in 1-month-old male mouse left ventricular tissue, showing 772 differentially expressed genes (DEGs)—485 upregulated and 287 downregulated—in Prdm16CKO versus wild-type hearts. (A) PANTHER gene ontology (GO) analysis was used for functional enrichment. Of 772 DEGs, 112 genes were categorized into 17 specific GO classes with significantly functional expression patterns (FDR P-value < 0.05, fold-enrichment > 2). The GO term “Regulation of blood pressure” ranked highest in fold-enrichment, with 4 genes (Adra1a, Nos1, Nppa, and Nppb) included. (B) Comparison of RNA-seq results and qRT-PCR for 4 genes in 1-month-old male mouse left ventricular tissue. (C) qRT-PCR of 4 genes in 5-month-old mouse left ventricular tissue in female Prdm16CKO versus control. Error bars, mean ± SEM; number (N), number of mice; statistical significance by student’s t-test, c (P < 0.005).