Fig 2: Serum expression of S100A8 (a), S100A9 (b), TfR1 (c), and SAP (d) detected by ELISA in the different clinical groups, respectively. Increased S100A8 and S100A9 serum levels were observed for all PQ poisoning patients (n = 21) compared to healthy controls (n = 21). Conversely, PQ poisoning groups showed significantly lower serum levels of TfR1 and SAP than the healthy group.

Fig 3: IHC analysis of S100A8 and S100A9 expression in lung tissue from PQ-treated rat and healthy controls. (a) and (b) Absence of staining for S100A8 and S100A9 in the normal lung tissue, respectively. (c) and (d) Marked S100A8 and S100A9 staining in lung tissue from rat treated with PQ. (Original magnification, 40×. Scale bars = 50 µm). Results of S100A8 (e) and S100A9 (f) immunohistochemistry in the cytoplasm and cell membrane in the lung tissues were quantitated by average optical of positive staining per 200 field.