Fig 1: Analysis of taxa with significant differences at genus level. (A) Taxa with significant differences at genus level between the CSVD and HC groups. P-value was obtained using Metastats analysis, and Q-value was obtained using FDR correction. (B, C) Correlation analysis of MMSE and MoCA scores with taxa with significant differences at genus level in CSVD patients. (D, E) Correlation analysis of plasma levels of S100ß and TNF-a with taxa with significant differences at genus level in CSVD patients. CSVD, cerebral small vessel disease; HC, healthy control; NIHSS, National Institutes of Health Stroke Scale; MMSE, Mini-mental State Examination; MoCA, Montreal Cognitive Assessment; S100ß, S100beta protein; TNF-a, tumor necrosis factor-alpha.