Description
ASB-xIV cells, derived from a female Balb/c mouse, resemble a large cell carcinoma induced by chrysotile asbestos in mouse lung cells. These monolayer adherent cells exhibit an epithelial morphology, making them an excellent representative model for studying primary squamous cell carcinoma (PSCC). ASB-xIV is known to be an 'inflamed' or 'hot' tumor, showcasing heightened sensitivity to immunotherapy. Thus, ASB-xIV cells are used to investigate the effectiveness of immunotherapeutic approaches. Specifically, these cells exhibit notable responsiveness to ICT (immune checkpoint therapy). Retinoids have shown promise in inhibiting the growth of transplanted carcinomas in mice. Conversely, vitamin C has not demonstrated any effects. Additionally, these monolayer adherent cells exhibit robust and stable growth properties, ensuring the establishment of reliable and consistent in vitro cultures for conducting experiments. However, ASB-xIV cells show a relatively slow doubling time of approximately 70 hours