Fig 1: Simplified coagulation cascade and complement system featuring transcriptomics, proteomics, and metabolomics regulations of systemic lupus erythematosus patients compared with healthy controls, according to KEGG nomenclatureGenes are presented as ovals, proteins as rectangles, metabolites by trapezoid. Regulation is color coded in which red stands for up regulated, green for down regulated, and black for unregulated. TFPI, tissue factor pathway inhibitor; F3, coagulation factor 3; F7, coagulation factor 7; F8, coagulation factor 8; F9, coagulation factor 9; F11, coagulation factor 11; F12, coagulation factor 12; F13, coagulation factor 13; F2, coagulation factor 2; F2R, F2 receptor; VWF, Von Willebrand factor; ATIII, antithrombin-III; PROZ, protein Z; PROS, protein S; FIB, fibrinogen; IF, complement factor I; DF, complement factor D; MAC, membrane attack complex; MASP2, mannan-binding lectin-associated serine protease 2; C4BP, C4b-binding protein; KEGG, kyoto encyclopedia of genes and genomes.