Fig 1: Effect of UP446 on inflammatory cytokines, and chemokines in LPS-induced ALI in rats. Male SD rats (n = 10) at the age of 9 weeks old were treated with the composition—UP446 at 125 mg/kg and 250 mg/kg orally for 7 days before the treatmpleent with LPS. On the 8th day, an hour after oral treatment, LPS was instilled intratracheal (i.t.) at 10 mg/kg dissolved with PBS. The control rats (n = 7) received only PBS. Treatment groups include G1 = control, G2 = LPS, G3 = LPS + UP446-125 mg/kg and G4 = LPS + UP446-250 mg/kg. G1 and G2 received the carrier vehicle (i.e., 0.5% CMC) during treatment period. Rats were sacrificed, serum for TNF-α (A) and IL-1β (B) and bronchoalveolar lavage (BAL) for IL-6 (C) and CRP (D) was collected 24 h post intratracheal LPS administration. The right lobe was homogenized for MIP-2/CINC-3 (E) activity analysis. * p ≤ 0.05; ** p ≤ 0.001; *** p ≤ 0.00001.
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