Human Interferon Alpha A (Alpha 2a) 11100-1 from PBL Assay Science

Product Specs
ItemHuman Interferon Alpha A (Alpha 2a)
CompanyPBL Assay Science
Price Pricing Info Supplier Page View Company Product Page
Catalog Number11100-1
Purity>95%
SpeciesHuman
ActivityActivity: 8.7 x 10⁸ u/mg
FormatPBS + 0.1% BSA
Quantity5 x 106 Units
Source/Expression SystemE.coli
Molecule NameIFN-Alpha 2a (IFN-Alpha A)
Gene Nameinterferon, alpha 2
Brand/TrademarkPBL Assay Science
TypeProtein
Molecular Weight19.2 kDa
NCBI Full Gene Nameinterferon alpha 2
NCBI Gene AliasesIFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF A

Additional Product Information

Protein/Peptide:
IFN Alpha A (Alpha 2a)

Protein/Peptide Species:
Human

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PBL Assay Science

131 Ethel Road West. Suite 6

Piscataway, New Jersey

United States

Phone: 1-877-725-8881
1-732-777-9123
1-732-777-9141

Company Profile

Website: www.pblassaysci.com

(1) USP18 enhances dengue virus replication by regulating mitochondrial DNA releaseScientific ReportsNovember 17, 2023Jenn-Haung Lai, De-Wei Wu, Chien-Hsiang Wu, Li-Feng Hung, Chuan-Yueh Huang, Shuk-Man Ka, Ann Chen, Ling-Jun Ho(21100-1) (used at 5 ug/ml), Anti-IFN-α receptor 1 (21370-1) (used at 5 ug/ml), recombinant human IFN‐α (11100-1) (used at 100 U/ml), recombinant mouse IFN‐α (12100-1) (used at 100 U/ml), and recombinant human IFN‐β

(2) MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophagesmBioOctober 31, 2023Robert Lodge, Zaikun Xu, Mckenna Eklund, Christina Stürzel, Frank Kirchhoff, Michel J. Tremblay, Tom C. Hobman, Éric A. Cohen(Sigma #SML1831; 10 µM) and PNU-74654 (R&D Systems #3534/5; 200 µM); cytokines IFN-α (PBL Assay Science #11100-1; 100 U/mL) and IL-10 (Peprotech #200-10; 40 ng/mL). MDM isolation, activation and transfection, and

(3) Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cellsbioRxivSeptember 22, 2023Alexia Carré, Zhicheng Zhou, Javier Perez-Hernandez, Fatoumata Samassa, Christiana Lekka, Anthony Manganaro, Masaya Oshima, Hanqing Liao, Robert Parker, Annalisa Nicastri, et al.above or without BSA with the following agents and final concentrations: IFN-α (PBL Assay Science, #11100–1; 2,000 U/mL), IFN-γ (RnD, #285-IF-100, 500 U/ml), carfilzomib (Selleckchem, #S2853; 50 nM) or ONX-0914

(4) ADAR1-mediated RNA editing promotes B cell lymphomagenesisiScienceJune 16, 2023Riccardo Pecori, Weicheng Ren, Mohammad Pirmoradian, Xianhuo Wang, Dongbing Liu, Mattias Berglund, Wei Li, Rafail Nikolaos Tasakis, Salvatore Di Giorgio, Xiaofei Ye, et al.recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, IFN-α,PBL Assay Science,Cat# 11100-1 ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, NEBuilder® HiFi DNA Assembly Cloning Kit

(5) ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcriptsFrontiers in Cell and Developmental BiologyJanuary 6, 2023Riccardo Pecori, Isabel Chillón, Claudio Lo Giudice, Annette Arnold, Sandra Wüst, Marco Binder, Marco Marcia, Ernesto Picardi, Fotini Nina Papavasiliou12-well plates in a total volume of 1 ml media containing 200 U/ml of IFN-α (PBL Assay Science, Cat# 11100–1). After 16 h, cells were collected, and RNA was extracted using a Qiagen RNeasy Plus kit (Qiagen, Cat#

(6) Nsp16 shields SARS–CoV ‐2 from efficient MDA5 sensing and IFIT1 ‐mediated restrictionEMBO reportsDecember 6, 2022Alina Russ, Sabine Wittmann, Yuta Tsukamoto, Alexandra Herrmann, Janina Deutschmann, Justine Lagisquet, Armin Ensser, Hiroki Kato, Thomas GrambergImageXpress Pico Automated Cell Imaging System (Molecular Devices). For IFN treatment, 10–100 U/ml type I IFN (IFNα2a, PBL‐11100‐1) were applied 18 h prior to infection or as indicated. Immunoblot analysis Cells were lysed in NP‐40

(7) Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS)Scientific ReportsDecember 1, 2022Shirley Tong, Maris A. Cinelli, Naglaa Salem El-Sayed, He Huang, Anika Patel, Richard B. Silverman, Sun Yangpurchased from GoldBio (1160-06-100; St. Louis, MO) and IFN-α was obtained from PBL Assay Science (11100-1; Piscataway, NJ). Antibodies Mouse monoclonal anti-human NOS1 (nNOS) (MAB2416-SP, Novus Biologicals,

(8) Diagnostic Accuracy of Methods for Detection of Antibodies against Type I Interferons in Patients with Endocrine DisordersJournal of Personalized MedicineNovember 24, 2022Nurana Nuralieva, Marina Yukina, Leila Sozaeva, Maxim Donnikov, Liudmila Kovalenko, Ekaterina Troshina, Elizaveta Orlova, Dmitry Gryadunov, Elena Savvateeva, Ivan Dedovimmobilized antigens, including IFN-ω (Cat # 300-02J, PeproTech, Cranbury, NJ, USA) and IFN-α-2a (Cat # 11100-1, PBL Assay Science, Piscataway, NJ, USA), were manufactured as described previously [22]. Each antigen

(9) A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signalingCellJune 23, 2022Alphonse N, Wanford JJ, Voak AA, Gay J, Venkhaya S, Burroughs O, Mathew S, Lee T, Evans SL, Zhao W, et al.recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, IFNα,Pbl Assay Science,Cat#11100-1 IFNβ,Peprotech,Cat#300-02BC IFNλ1,Peprotech,Cat#300-02L IFNγ,Peprotech,Cat#300-02 mIFNβ,R&D systems,Cat#12405-1 Z-VAD-FNK,Apexbio,Cat#A1902 Necrosulfonamide,Tocris,Cat#5025 W7,Calbiochem,CAS

(10) High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune ResponsemSystemsApril 26, 2022Tai L. Ng et al.stimulation by treating with interferon ɑ1 (Cell Signaling no. 8927) or interferon ɑ2b (PBL Assay Science no. 11100-1) at 50 ng/mL (final concentration in the well, 5 ng/mL). Twenty-four hours after treatment with interferon,

(11) Microarray-Based Detection of Antibodies against SARS-CoV-2 Proteins, Common Respiratory Viruses and Type I InterferonsVirusesDecember 20, 2021Elena Savvateeva, Marina Filippova, Vladimir Valuev-Elliston, Nurana Nuralieva, Marina Yukina, Ekaterina Troshina, Vladimir Baklaushev, Alexander Ivanov, Dmitry GryadunovYork, NY, USA), IFN-ω—interferon ω (300-02J, PeproTech, Cranbury, NJ, USA); IFN-α-2a—interferon α-2a (11100-1, PBL Assay Science, Piscataway, NJ, USA), AdV—adenovirus (8AV13, HyTest, Finland), PIV-1—parainfluenza virus type 1

(12) Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral ResponsesCellsSeptember 30, 2021Wüst S, Schad P, Burkart S, Binder M.of CRISPR/Cas9 Knockouts Validation by Immunoblotting Untreated or IFN-α2a stimulated (200 IU/mL; 11100-1, PBL Assay Science) A549 IRF1, IRF2, IRF3, IRF5, IRF7, IRF9, RIG-I, and RELA KO cells were washed with

(13) Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunityNature immunologySeptember 1, 2021Li P, Jiang M, Li K, Li H, Zhou Y, Xiao X, Xu Y, Krishfield S, Lipsky PE, Tsokos GC, et al.cytokines and antibodies Chemicals and cytokines used were as follows: recombinant human IFN α2b (11100–1, PBL assay science), RSL3 (S8155, Selleck), liproxstatin-1 (LPX-1) (S7699, Selleck), deferoxamine mesylate

(14) Comprehensive Analysis of Human Cytomegalovirus- and HIV-Mediated Plasma Membrane Remodeling in MacrophagesmBioAugust 31, 2021Ramona Businger et al.After differentiation, the cells were treated with 10 ng ml−1 IFN-α-2a (PBL Assay Science; catalog no. 11100-1) or IFN-γ (ImmunoTools; catalog no. 11343534) for 48 h, stained with the 31 validation antibodies, and

(15) CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1Scientific reportsJuly 21, 2021Durlanik S, Fundel-Clemens K, Viollet C, Huber HJ, Lenter M, Kitt K, Pflanz S.the culture: 20 ng/ml LPS (tlrl-b5lps, InvivoGen) + 50 ng/ml IFNγ (571104, BioLegend); 10 ng/ml IFNα (11100-1, PBL); 20 ng/ml IL-4 (130-093-922, Miltenyi Biotec) + 20 ng/ml IL-13 (571104, BioLegend); 20 ng/ml IL-10

(16) Fractional response analysis reveals logarithmic cytokine responses in cellular populationsNature communicationsJuly 7, 2021Nienałtowski K, Rigby RE, Walczak J, Zakrzewska KE, Głów E, Rehwinkel J, Komorowski M.were stimulated with 0, 25, 250, 2500, or 25000 U/mL recombinant human IFN-α2a (PBL Assay Science, #11100-1) diluted in R10 for 15 min at 37 °C. After washing with 5 mL cold Maxpar PBS (Fluidigm), cells were

(17) Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathwaysiScienceJune 25, 2021Lai JH, Wu DW, Wu CH, Hung LF, Huang CY, Ka SM, Chen A, Chang ZF, Ho LJ.GMCSF,PeproTech,Cat#31503 Mouse MCSF,PeproTech,Cat#31502 Recombinant Human IFN-α,PBL Assay Science,Cat#11100-1 Recombinant mouse IFN-α,PBL Assay Science,Cat#12100-1 Recombinant Human CCL19/MIP-3β,R&D systems,Cat#361-MI-025 Recombinant

(18) Type-I interferon signatures in SARS-CoV-2 infected Huh7 cellsCell Death DiscoveryJune 1, 2021Xi Chen et al.resuspended in sterile physiological water at a final concentration of 20 mg/mL. Interferon-α 2a (IFN-α; #11100-1) and interferon-β (IFN-β; #11415-1) were purchased from PBL assay science (USA). Antibodies Antibodies

(19) Oncogenic KIT modulates type I interferon–mediated antitumor immunity in GISTCancer Immunology ResearchMay 1, 2021Mengyuan Liu, Mark S. Etherington, Andrew Hanna, Benjamin D. Medina, Gerardo A. Vitiello, Timothy G. Bowler, Nesteene J. Param, Lillian Levin, Ferdinand Rossi, Ronald P. DeMatteotreated for 6 to 24 hours in serum-complete RPMI medium with 1000 U/ml IFNα (PBL Assay Science, cat# 11100–1), 100 ng/mL IFNγ (R&D Systems, cat# 285-IF), or 100 ng/mL TNF (R&D Systems, cat# 210-TA-005). Imatinib

(20) The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25's RNA Binding AbilitymBioApril 13, 2021Chiang C, Dvorkin S, Chiang JJ, Potter RB, Gack MU.verify that the original sequences were correct. Recombinant IFN-α2 (PBL Assay Science catalog no. 11100-1) and poly(dA·dT)/LyoVec (InvivoGen catalog no. tlrl-patn) were used according to the manufacturers’

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Human Interferon Alpha A (Alpha 2a) from PBL Assay Science

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Human Interferon Alpha A (Alpha 2a) from PBL Assay Science

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