Anti-COL3A1 antibodies are used in the immunodetection of the protein collagen type III alpha 1 chain. In humans, the canonical protein has a reported length of 1466 amino acid residues and a mass of 138.6 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the testis. A member of the Fibrillar collagen protein family, COL3A1 is known to be involved with cell matrix adhesion and nervous system development.
The COL3A1 marker can be used to identify Myofibroblast Cells and Type 2 Thymic Fibroblasts.* Synonyms for this target antigen include EDSVASC, PMGEDSV, collagen alpha-1(III) chain, Ehlers-Danlos syndrome type IV, autosomal dominant, alpha-1 type III collagen, and EDS4A. COL3A1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 960 citations in the literature describe the use of COL3A1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4