Anti-RAP1GAP antibodies are used in the immunodetection of the protein RAP1 GTPase activating protein. In humans, the canonical protein has a reported length of 663 amino acid residues and a mass of 73.4 kDa. Its subcellular localization is in the Golgi and membrane. Up to 4 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. RAP1GAP is known to be a GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. The RAP1GAP marker can be used to identify Medullary Thick Ascending Limb Cells.* Synonyms for this target antigen include RAP1GAP1, RAP1GAPII, RAPGAP, rap1 GTPase-activating protein 1, and RAP1GA1. RAP1GAP gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4