Anti-CRNN antibodies are used in the immunodetection of the protein cornulin. In humans, the canonical protein has a reported length of 495 amino acid residues and a mass of 53.5 kDa. Its subcellular localization is in the cytoplasm. It is reported to be expressed in the basal skin layer. A member of the S100-fused protein family, CRNN is reported to promote cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. The CRNN gene has been associated with the disease, Esophageal cancer. Synonyms for this target antigen include DRC1, PDRC1, 53 kDa putative calcium-binding protein, 53 kDa squamous epithelial-induced stress protein, 58 kDa heat shock protein, and C1orf10. CRNN gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of CRNN antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.