Anti-ABCB11 antibodies are used in the immunodetection of the protein ATP binding cassette subfamily B member 11. In humans, the canonical protein has a reported length of 1321 amino acid residues and a mass of 146.4 kDa. Its subcellular localization is in the cell membrane. It is noted to be expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ. A member of the ABCB protein family, ABCB11 is known to catalyze the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Synonyms for this target antigen include BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP, bile salt export pump, and ABC16. ABCB11 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species.