Anti-CORO1A antibodies are used in the immunodetection of the protein coronin 1A. In humans, the canonical protein has a reported length of 461 amino acid residues and a mass of 51 kDa. Its subcellular localization is in the cytoplasmic vesicles and cytoplasm. It is reported to be expressed in the brain, thymus, spleen, bone marrow and lymph node. A member of the WD repeat coronin protein family, CORO1A is believed to be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion.
The CORO1A marker can be used to identify Alveolar Macrophages CCL3+ Cells, Alveolar Macrophages, Alveolar Macrophages Proliferating Cells, Alveolar Macrophages Mt+ Cells, and Interstitial Macrophages.* Synonyms for this target antigen include CLIPINA, HCORO1, IMD8, TACO, p57, clipin-A, coronin, actin binding protein, 1A, and CLABP. CORO1A gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. A number of CORO1A antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4