Anti-C3 and PZP like alpha-2-macroglobulin domain containing 8 antibodies are used for the immunodetection of the protein encoded by the CPAMD8 gene. In humans, the canonical protein has a reported length of 1885 amino acid residues and a mass of 206.7 kDa. Its subcellular localization is in the cell membrane and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be highly expressed in the kidney, brain and testis and to a lower extent in the heart, liver and small intestine. A member of the Protease inhibitor I39 (alpha-2-macroglobulin) protein family, it is known to be involved with eye development. Post-translational modifications have been described, including protein cleavage and glycosylation. Other names for this target antigen include K-CAP, VIP, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8, alpha-2 macroglobulin family protein VIP, and ASGD8. Gene orthologs have been identified in the bovine, frog, zebrafish, chimpanzee and chicken species.