Anti-isocitrate dehydrogenase (NADP(+)) 2 antibodies are used for the immunodetection of the protein encoded by the IDH2 gene. In humans, the canonical protein has a reported length of 452 amino acid residues and a mass of 50.9 kDa. Its subcellular localization is in the mitochondria. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Isocitrate and isopropylmalate dehydrogenases protein family, it is reported to play a role in intermediary metabolism and energy production. Post-translational modifications have been described, including acetylation. The gene encoding this protein is implicated in D-2-hydroxyglutaric aciduria. Other names for this target antigen include ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH, isocitrate dehydrogenase [NADP], mitochondrial, and D2HGA2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.