Anti-DNASE2 antibodies are used in the immunodetection of the protein deoxyribonuclease 2, lysosomal. In humans, the canonical protein has a reported length of 360 amino acid residues and a mass of 39.6 kDa. Its subcellular localization is in the lysosomes. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in monocytes/macrophages. A member of the DNase II protein family, DNASE2 is known to be involved with the apoptotic pathway and enucleate erythrocyte differentiation. Post-translational modifications have been described, including N-glycosylation. The DNASE2 gene has been associated with the disease, Autoinflammatory-pancytopenia syndrome. Synonyms for this target antigen include DNASE2A, DNL, DNL2, deoxyribonuclease-2-alpha, DNase II alpha, DNase II, lysosomal, R31240_2, and AIPCS. DNASE2 gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species.