Anti-BHLHE22 antibodies are used in the immunodetection of the protein basic helix-loop-helix family member e22. In humans, the canonical protein has a reported length of 381 amino acid residues and a mass of 37 kDa. Its subcellular localization is in the nucleus. It is notably expressed in the cerebellum and hippocampus. BHLHE22 is reported to inhibit DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. The BHLHE22 marker can be used to identify Hippocampal Gyrus CA1-3 Neurons.* Synonyms for this target antigen include Beta3, Beta3a, CAGL85, TNRC20, class E basic helix-loop-helix protein 22, and BHLHB5. BHLHE22 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4