Anti-CPVL antibodies are used in the immunodetection of the protein carboxypeptidase vitellogenic like. In humans, the canonical protein has a reported length of 476 amino acid residues and a mass of 54.2 kDa. It is reported to be expressed in macrophages but not in other leukocytes. A member of the Peptidase S10 protein family, CPVL is suspected to be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Post-translational modifications have been described, including glycosylation. The CPVL marker can be used to identify CD8?+ Thymic Conventional Dendritic Cells.* Synonyms for this target antigen include probable serine carboxypeptidase CPVL, CP-Mac carboxypeptidase, VCP-like protein, carboxypeptidase WUG, vitellogenic carboxypeptidase-like protein, and HVLP. CPVL gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4