Anti-NEK2 antibodies are used in the immunodetection of the protein NIMA related kinase 2. In humans, the canonical protein has a reported length of 445 amino acid residues and a mass of 51.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is notably expressed in the tonsil, testis, lymph node, and appendix. A member of the NEK Ser/Thr protein kinase protein family, NEK2 is reported to be a protein kinase, which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Post-translational modifications have been described, including phosphorylation. The NEK2 gene has been associated with the disease, Retinitis pigmentosa. Synonyms for this target antigen include NEK2A, NLK1, PPP1R111, RP67, serine/threonine-protein kinase Nek2, and HsPK21. NEK2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.