Anti-ACTN2 antibodies are used in the immunodetection of the protein actinin alpha 2. In humans, the canonical protein has a reported length of 894 amino acid residues and a mass of 103.9 kDa. Its subcellular localization is in the cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in both skeletal and cardiac muscle. A member of the Alpha-actinin protein family, ACTN2 is known to be involved with cytoskeleton organization and cell adhesion. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include CMH23, CMYP8, MPD6, MYOCOZ, alpha-actinin-2, F-actin cross-linking protein, alpha-actinin skeletal muscle, and CMD1AA. ACTN2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 1800 citations in the literature describe the use of Actn2 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.