Anti-TANK antibodies are used in the immunodetection of the protein TRAF family member associated NFKB activator. In humans, the canonical protein has a reported length of 425 amino acid residues and a mass of 47.8 kDa. Its subcellular localization is in the cytoplasm. Up to 3 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. TANK is known to be an adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Synonyms for this target antigen include ITRAF, TRAF2, TRAF family member-associated NF-kappa-B activator, and I-TRAF. TANK gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of TANK antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.