mRNA purification kits are designed to isolate intact messenger RNA from cells, tissues, or RNA preparations for downstream applications in the study of gene expression and transcriptomics. For instance, some kits feature all necessary reagents to remove contaminants such as genomic DNA and nucleases. Kits for isolating poly A+ mRNA typically utilize oligo dT coupled to magnetic particles for convenient handling and streamlined protocols. Many are also designed to effectively deplete ribosomal RNA to yield pure, high-quality mRNA.