96 Multiwell Plate From Corning Life Sciences for Spheroid Culture

January 10, 2024

Università degli Studi Milano-Bicocca
Industrial Biotechnologies
Graduate Student

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Company:

Corning Life Sciences

Product Name:

Spheroid microplates, 96 well, round black/clear bottom, ULA

Catalog Number:

4520

The research aims to evaluate cytotoxicity and drug responses of lipidic nanoparticles loaded with drugs on human osteosarcoma cells. Especially the evaluation is conducted in a 3D context to better mimic the tumor environment.

Experimental Design and Results Summary

Application

I recently used Corning spheroid microplates in my research for growing consistently spheroids of human osteosarcoma cells. The spheroids were then used for different studies like drug and nanoparticles cytotoxicity, nanoparticles uptake, spheroids inflammation.

Tips

The round black/clear bottom design provides the perfect balance between light-blocking for certain assays and clarity for imaging.

DOI or PMID #

N/A

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Summary

The Good

Loading and retrieving cells from the wells is really easy.

The Bad

Expensive.

The Bottom Line

They effectively and consistently promote the formation of spheroids by preventing cell adhesion to the plate surface. This feature is crucial for creating physiologically relevant 3D cell cultures.

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