Tocris Bioscience
SIN-1 chloride
0756
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SIN-1 generates peroxinitrite from super oxide and nitric oxide. Effects of SIN-1 (20 μM in pH 7.4, kept at 37 °C for 2 h) on the MPO (10 nM)-H2O2 (25 μM)-chloride system were analyzed by APF fluorescence measurements. SIN-1 inhibited MPO activity, as shown by reduced fluorescence.
Chemistry - enzyme activity
Myeloperoxidase
N/A
SIN-1 generated superoxide and nitric oxide that reacted with each other to generate peroxynitrite. The final product inhibited MPO activity measured by APF.
Worked as expected
SIN-1 can be used to study chemistry of superoxide, nitric oxide and peroxynitrite.