Tocris Bioscience
E-4031 dihydrochloride
1808
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To investigate role of delayed rectifier potassium channels, hERG, in cardiac action potential of guinea pig ventricular myocytes, we used E-4031, a IKr blocker.
Cardiac electrophysiology
Primary guinea pig ventricular cardiomyocytes
N/A
A representative action potential of a guinea pig cardiomyocyte before and after superfusion with 500 nM E-4031 for 5 min and stimulated at a frequency of 1 Hz in a while cell patch clamp mode.
Works as expected.
E-4031 significantly shortened action potential duration of guinea pig ventricular cardiomyocytes.