Neuronal activity demands high energy, with the brain relying on mitochondrial respiration and glycolysis to maintain function. Disruptions in these pathways are common in aging and neurodegenerative diseases. Traditional methods to study brain metabolism—like cultured neurons or isolated mitochondria—lack the complexity of actual brain tissue and require large sample sizes. This application note introduces the Agilent Seahorse XF Flex Analyzer and a streamlined workflow for assessing energy metabolism in small brain tissue samples. Download now to learn how researchers can measure key metabolic indicators such as oxygen consumption rate (OCR), providing real-time insights into mitochondrial function and cellular health.
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