Biochemical assays can be used to identify drug candidates able to alter ligand-receptor interactions in a high-throughput setting. These biochemical assays are complemented by quantitative cell-based reporter assays, which provide the means to investigate immune checkpoints in a cellular environment without the limitations and variability associated with assays performed in primary donor cells. These complementary techniques provide researchers with a comprehensive approach for identifying and developing the next generation of immunotherapy treatments.
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