Fig 1: RBP4 expression levels and the correlation with ?ASDAS-CRP in the validation cohort. (A) Relative serum RBP4 expression levels between HCs and AS patients at baseline, week 12, and week 24. Data were shown as scatter plots (mean ± SEM). (B) Relative baseline RBP4 expression levels in HCs and in AS patients with and without major improvement in ASDAS-CRP (?ASDAS-CRP = 2 and ?ASDAS-CRP < 2) at week 24. Data were shown as scatter plots (mean ± SEM). (C) Linear correlation between baseline RBP4 levels and ?ASDAS-CRP at week 24. *P-value < 0.05, **P-value < 0.01, ***P-value < 0.001. ?ASDAS-CRP, improvements of Ankylosing Spondylitis Disease Activity Score-C-Reactive Protein; HC, healthy control; AS, ankylosing spondylitis; n.s., not significant.
Fig 2: Relative expression levels in seven pivotal DEPs among samples from all AS patients, HCs, patients pre- and post-treated with ADA in the discovery cohort. Two proteins (SAA1 and IRF6) were expressed higher in AS group and down-regulated after 24-week ADA treatment, and five proteins (RBP4, ROR2, osteocalcin, PDGFR-ß, and ADAMTS-10) were expressed lower and up-regulated after ADA treatment. Data were shown as box and whisker plots (mean ± SEM) and before-after plots for pair samples. *P-value < 0.05, **P-value < 0.01, ***P-value < 0.001. DEP, differentially expressed protein; HC, healthy control; AS, ankylosing spondylitis; ADA, adalimumab; Pre-ADA, pre-treated with ADA; Post-ADA, post-treated with ADA.
Supplier Page from RayBiotech for Human RBP-4 ELISA