Fig 1: DHEA-shaped gut microbiota reproduced glucose intolerance, polycystic ovaries and reproductive hormone disorders in FMT recipients. a Timeline for animal experiments in FMT recipients. Yellow bars represent normal feeding with standard chow and non-acidified drinking water. Other treatments are indicated in the schema. b Bodyweight, c FBG, d GTT, e area under the curve of GTT, f typical oestrous cycles and g H&E staining of typical ovaries. * indicates CL, and cyst-like follicles are indicated by #. Black arrows indicate normal granulosa cell layers. Red arrows indicate attenuated granulosa cell layers. Scale bar = 1000 µm (left) and 200 µm (right). h serum TT levels, i serum SHBG levels, j FAI, k serum LH levels, l serum FSH levels and m LH:FSH ratio. Data are given as mean ± SEM. n = 6 rats per group. * p < 0.05; ** p < 0.01
Fig 2: DHEA-induced glucose metabolism, ovarian morphology, and reproductive hormone level alterations in conventional and antibiotic-treated rats. a Bodyweight, b FBG, c GTT, d area under the curve of GTT, e oestrous cycle examination and f H&E staining of representative ovaries. * indicates CL, and cyst-like follicles are indicated by #. Black arrows indicate normal granulosa cell layers. Red arrows indicate attenuated granulosa cell layers. Scale bar = 1000 µm (left) and 200 µm (right). g serum TT levels, h serum SHBG levels, i FAI, j serum LH levels, k serum FSH levels and l LH:FSH ratio, DHEA + ABX, DHEA + antibiotics. Data are given as mean ± SEM. n = 6 rats per group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001
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