Fig 1: ACKR4 regulates CCL21 level in NPC tumor tissue. The intratumoral levels of (A) CCL21, (B) CCL19, (C) CCL25 and (D) CXCL13 were measured in tumors with different levels of ACKR4 expression. The concentration of CCL21 was evidently reduced by ACKR4 overexpression in NPC tumor tissue. ***P<0.001 and ****P<0.0001. NS, no significant difference. ACKR4, atypical chemokine receptor 4; NPC, nasopharyngeal carcinoma; WT, wild-type; EV, empty vector; KD, knockdown; OE, overexpression; CCL, C-C motif chemokine ligand; CXCL, C-X-C motif chemokine ligand.