Description
Product Characteristics:
GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (Gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct.
Subcellular location: Cell membrane
Synonyms: GABAA receptor, GABAA receptor subunit pi, GABRP, Gamma aminobutyric acid GABA A receptor pi, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid receptor subunit pi, Gamma-aminobutyric acid receptor subunit pi, GBRP_HUMAN, MGC126386, MGC126387.
Target Information: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. [provided by RefSeq, Jul 2008]