Description
Product Characteristics:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008].
Subcellular location: Cell membrane
Synonyms: GF 1R beta, IGF I receptor beta, IGF1R beta, IGFIR beta, Insulin like growth factor 1 receptor beta, CD221, CD221 antigen, IGF1 Receptor, IGF 1 receptor, IGF 1R, IGF I receptor, IGF1R, IGFIR, IGFIRC, Insulin like growth factor 1 receptor, Insulin like growth factor 1 receptor precursor, JTK13, MGC142170, MGC142172, IGF1R_HUMAN.
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