Description
Product Characteristics:
Relaxin Receptor 3 is a G protein-coupled receptor that binds Relaxin 3 and influences differentiation and maintenance of the nervous system. Relaxin Receptor 3 shares sequence similarity with somatostatin receptors and angiotensin receptors. It mediates central processing of sensory signals in the rat and is thought to be a modulator of stress responses. Relaxin Receptor 3 is present in the brain, with highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, and low level expression in cerebellum. In peripheral tissues there are high levels in adrenal glands and low levels in pancreas, salivery gland, placenta, mammary gland and testis.
Subcellular location: Cell membrane
Synonyms: Relaxin Receptor 3, G protein coupled receptor GPCR135, G protein coupled receptor SALPR, G-protein coupled receptor SALPR, GPCR SALPR, GPCR 135, GPCR135, Gprotein coupled receptor SALPR, Relaxin 3 receptor 1, Relaxin 3 receptor1, Relaxin 3/INSL7 receptor 1, Relaxin 3/INSL7 receptor1, Relaxin family peptide receptor 3, Relaxin family peptide receptor3, Relaxin/insulin like family peptide receptor 3, Relaxin3 receptor 1, Relaxin3 receptor1, RL3 R1, RL3R 1, RL3R1, RLN3 receptor 1, RLN3 receptor1, RLN3R1, RXFPR3, SALP R, SALPR, somatostatin and angiotensin like peptide receptor, RL3R1_HUMAN.
Target Information: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity)