Description
Product Characteristics:
PCSK1N is a 260 amino acid protein that is both secreted and localized to the trans-Golgi network. Expressed in pancreas and brain, PCSK1N is thought to play a role in the control of the neuroendocrine secretory pathway and may also be involved in PCSK1 inhibition. The gene encoding PCSK1N maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination, as an X and a Y chromosome lead to normal male development, while two copies of an X chromosome lead to normal female development. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy.
Synonyms: b-LEN, b-PEN-LEN, b-SAAS, Big LEN, granin like neuroendocrine peptide, l-LEN, l-SAAS, N-proSAAS, PCSK1_RAT, Pcsk1n, pro-SAAS, Proprotein convertase 1 inhibitor, Proprotein convertase subtilisin/kexin type 1 inhibitor, PROSAAS, SAAS, SAAS CT1-49, SAAS CT25-40.
Target Information: Members of the subtilisin-like proprotein convertase family process latent precursor proteins into their biologically active products. The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. [provided by RefSeq, Nov 2012]