InVivoMab anti-mouse IL-6R BE0047-R005mg from Bio X Cell

Description

Bio X Cell InVivoMAb anti-mouse IL-6R Monoclonal Antibody has the following reported applications: in vivo blocking of IL-6/IL-6R signaling, in vitro blocking of IL-6R signaling. It features greater than 95% purity, ultra-low endotoxin levels, and are preservative, stabilizer, and carrier protein-free

Product Specs
ItemInVivoMab anti-mouse IL-6R
CompanyBio X Cell
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberBE0047-R005mg
Quantity5 mg
Applicationsin vivo blocking of IL-6/IL-6R signaling, in vitro blocking of IL-6R signaling
ConcentrationLot specific,typically between 4-11 mg/ml
Conjugate/TagUnconjugated
ReactivityMouse
TargetIL-6R
IsotypeIgG2b, κ
Clone15A7
Hostrat
NCBI Full Gene Nameinterleukin 6 receptor, alpha
NCBI Gene AliasesCD126, IL-6R, IL-6R-alpha, IL-6RA, Il6r
ClonalityMonoclonal
ImmunogenOKT-4 hybridoma cells
Antibody TypePrimary Antibody
Purity>95%, Determined by SDS-PAGE
FormatPBS, pH 7.0, Contains no stabilizers or preservatives
Research AreaCytokine Receptor, Immunology, Neuroscience

Specifications/Features

Other available quantities: Available in 1, 5, 10, 25, 50, 100 mg and bulk sizes. Academic discount available.

Endotoxin: <2EU/mg (<0.002EU/µg), Determined by LAL gel clotting assay

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Bio X Cell

39 Labombard Rd

Lebanon, NH 03766

United States

Phone: 1-866-787-3444

Email: customerservice@bxcell.com

Company Profile

Website: bioxcell.com

(1) IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old ageNature communicationsApril 7, 2015Tsukamoto H, Senju S, Matsumura K, Swain SL, Nishimura Y.

(2) Role of IL-6 in Mycobacterium avium--associated immune reconstitution inflammatory syndromeJournal of immunology (Baltimore, Md. : 1950)January 15, 2014Barber DL, Andrade BB, McBerry C, Sereti I, Sher A.

(3) The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chainThe Journal of biological chemistrySeptember 20, 2013Pham D, Walline CC, Hollister K, Dent AL, Blum JS, Firulli AB, Kaplan MH.

(4) Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsetsBloodJune 14, 2012Markey KA, Koyama M, Kuns RD, Lineburg KE, Wilson YA, Olver SD, Raffelt NC, Don AL, Varelias A, Robb RJ, et al.

(5) Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiationBloodSeptember 24, 2009Piconese S, Gri G, Tripodo C, Musio S, Gorzanelli A, Frossi B, Pedotti R, Pucillo CE, Colombo MP.

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