Fig 2: Kaplan Meier survival estimates based on immunohistochemical FAS expression both for recurrence free survival A. and overall survival B. Furthermore, the prognostic effect of CD8-positive TILs is shown in both ER-negative (C. RFS, D. OS) and ER-positive tumors (E. RFS, F. OS). P-values represent log-rank survival test.

Fig 3: Kaplan Meier survival estimates based on CD8+ tumor infiltrating lymphocytes (TILs) stratified on FAS expression in both ER-negative and ER-positive tumorsIn patients with ER-negative tumors with high FAS expression, the high presence of CD8-positive is prognostic for a significantly higher survival A. This prognostic effect is not observed in ER-negative tumors with low FAS expression B. nor in ER-positive tumors C, D. P-values represent log-rank survival test.

Fig 4: Representative examples of immunohistochemical staining for FAS expression and CD8-positive TILs (10x magnification)The FAS-negative sample only contains some FAS-positive infiltrating lymphocytes A. whereas the FAS-positive sample shows homogenous membranous FAS expression in the tumor cells B. The CD8-low sample showed no infiltration of CD8-positive TILs C. whereas the CD8-high sample shows large numbers of CD8-positive TILs D.