Anti-Progerin antibody [13A4] ab66587 from Abcam

Product Specs
ItemAnti-Progerin antibody [13A4]
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab66587
Antibody TypePrimary
Quantity10 UG, 100 UG
IsotypeIgG1
HostMouse, Nude mouse
ClonalityMonoclonal
ApplicationsWestern blot
Clone13A4
Conjugate/TagUnconjugated
Concentration1 mg/ml
Research AreaEpigenetics
Gene NameLMNA
ReactivityHuman
TargetProgerin

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1Nat AgingFebruary 1, 2023Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, et al.anti-lamin A/C 1:3,000 (Abcam, catalog no. ab108595), anti-progerin (13A4) 1:1,000 (Abcam, catalog no. ab66587), anti-P-H3 (S10) 1:1,000 (Cell Signaling Technology (CST), catalog no. 3377), anti-H3K9me3 1:10,000

(2) Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in miceThe EMBO journalJanuary 4, 2023Hu Q, Zhang N, Sui T, Li G, Wang Z, Liu M, Zhu X, Huang B, Lu J, Li Z, et al.siCDK7#1_rev (5′‐ UUCUAAUCCUUGAAGAGUCTT‐3′). The following antibodies were used: antibodies against progerin (ab66587; Abcam); HMGA1 (#7777 for WB; Cell Signaling Technology, ab4078 for ChIP; and ab129153 for IHC; Abcam);

(3) Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathwayNucleic Acids ResearchSeptember 23, 2022Scott Maynard et al.α-tubulin (ab4074, Abcam), Histone H3 (ab1791, Abcam), lamin A/C (sc-20681; Santa Cruz), progerin (ab66587; Abcam), PAR (ab14460; Abcam), SIRT1 (04-1557; Millipore), PGC1α (NBP1-04676ss; Novus), NAMPT (A0256;

(4) Mesenchymal stem cells derived from patients with premature aging syndromes display hallmarks of physiological agingLife science allianceSeptember 14, 2022Trani JP, Chevalier R, Caron L, El Yazidi C, Broucqsault N, Toury L, Thomas M, Annab K, Binetruy B, De Sandre-Giovannoli A, et al.prepared in 5% milk in PBS-T, anti-lamin A/C (1:100, Sc6215; Santa Cruz), and anti-progerin (1:100, ab66587; Abcam). Membranes were washed in PBS-T (4 × 5 min) and then incubated 1 h at RT with secondary antibodies

(5) Vascular senescence in progeria: role of endothelial dysfunctionEur Heart J OpenJuly 1, 2022Xu Q, Mojiri A, Boulahouache L, Morales E, Walther BK, Cooke JP.were analysed by using Image-J software. Primary antibodies included the following: progerin (Abcam #ab66587), histone H1 (Abcam #61177), HP1α (Cell Signalling #2616s), TRF1 (Novus #NB110-68281), TRF2 (Novus #NB110-57130),

(6) Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin AScientific reportsApril 27, 2021Kang SM, Yoon MH, Lee SJ, Ahn J, Yi SA, Nam KH, Park S, Woo TG, Cho JH, Lee J, et al.(1:10,000; sc-376248; Santa Cruz Biotechnology), progerin (1:300; sc-81611; Santa Cruz Biotechnology and ab66587; Abcam, Cambridge, UK), Ki67 (1:400; ab15580; Abcam), H3K9me3 (1:400 and 1:2000; ab8898; Abcam), p16-INK4A

(7) Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndromeCommunications biologyJanuary 4, 2021Kang SM, Yoon MH, Ahn J, Kim JE, Kim SY, Kang SY, Joo J, Park S, Cho JH, Woo TG, et al.Santa Cruz Biotechnology), anti-Progerin (1:100; sc-81611; Santa Cruz Biotechnology), anti-Progerin (1:300; ab66587; Abcam, Cambridge, UK), anti-Ki67 (1:200; Ab15580; Abcam), anti-cyclin B1 (1:100; sc-594; Santa Cruz Biotechnology

(8) Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesisEMBO reportsOctober 5, 2020Fan JR, You LR, Wang WJ, Huang WS, Chu CT, Chi YH, Chen HC.awaits for future research efforts. Materials and Methods Antibodies and reagents The anti‐progerin (ab66587), anti‐lamin A (ab8980), anti‐aquaporin 1 (ab65837), anti‐Arl3b (ab136648), and anti‐pericentrin (ab4448)

(9) Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathyPloS oneJanuary 1, 2018Messner M, Ghadge SK, Goetsch V, Wimmer A, Dörler J, Pölzl G, Zaruba MM.glass slides. For Immunohistochemistry staining, deparaffinized sections were incubated with progerin antibody (ab66587, Abcam) followed by Vectastain Elite ABC kit (AK-5000, Vector laboratories, Cambridgeshire, UK) and

(10) One week of exposure to sunlight induces progerin expression in human skinAdvances in Dermatology and Allergology/Post?py Dermatologii i AlergologiiDecember 31, 2017Aleksandra Lesiak, Igor Bednarski, Michal Rogowski-Tylman, Michal Sobjanek, Anna Wozniacka, Marian Danilewicz, Anthony Young, Joanna Narbutt

(11) Antisense-Based Progerin Downregulation in HGPS-Like Patients’ CellsCellsJuly 11, 2016Karim Harhouri, Claire Navarro, Camille Baquerre, Nathalie Da Silva, Catherine Bartoli, Frank Casey, Guedenon Koffi Mawuse, Yassamine Doubaj, Nicolas Lévy, Annachiara De Sandre-Giovannolipolyclonal anti-Lamin A/C (sc-6215, Santa Cruz Biotechnology), 1:1000 mouse monoclonal anti-Progerin (ab66587, Abcam, Cambridge, UK), 1:1000 mouse monoclonal anti-actin (MAB1501, Merck Millipore, Darmstadt, Germany)

(12) Mutant lamin A links prophase to a p53 independent senescence programCell cycle (Georgetown, Tex.)August 3, 2015Olga Moiseeva, Frédéric Lessard, Mariana Acevedo-Aquino, Mathieu Vernier, Youla S Tsantrizos, Gerardo Ferbeyre

(13) Truncated prelamin A expression in HGPS-like patients: a transcriptional studyEuropean Journal of Human GeneticsAugust 1, 2015Florian Barthélémy et al.used were goat anti-lamin A/C (SC-6215; Santa Cruz Biotechnology, CA, USA) and mouse anti-progerin (ab66587; Abcam, Paris, France), respectively used at 1/100 and 1/50 dilutions. The secondary antibody used was,

(14) Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic NucleiPathobiologyJanuary 1, 2015Helal Endisha, Jacqueline Merrill-Schools, Min Zhao, Molly Bristol, Xu Wang, Nard Kubben, Lynne W. Elmoreantibodies: rabbit anti-SIRT6 (No. 2590; Cell Signaling Technology); mouse anti-progerin antibody (ab66587; Abcam) or mouse monoclonal anti-β-actin (sc-47778; Santa Cruz Biotechnology), as recommended by the

(15) Antisense oligonucleotide induction of progerin in human myogenic cellsPloS oneJanuary 1, 2014Yue-Bei Luo, Chalermchai Mitrpant, Abbie M Adams, Russell D Johnsen, Sue Fletcher, Frank L Mastaglia, Steve D Wilton

(16) Longwave UV light induces the aging-associated progerinThe Journal of investigative dermatologyJuly 1, 2013Hirotaka Takeuchi, Thomas M Rünger

(17) Investigation of age-related changes in LMNA splicing and expression of progerin in human skeletal musclesInternational journal of clinical and experimental pathologyJanuary 1, 2013Yue-Bei Luo, Chalermchai Mitrpant, Russell D Johnsen, Victoria A Fabian, Sue Fletcher, Frank L Mastaglia, Steve D Wilton

(18) Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndromeNatureApril 14, 2011Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, et al.obtained from the following sources. Abcam: anti-NANOG (ab21624), anti-H3K9Me3 (ab8898), anti-progerin (ab66587), anti-emerin (ab14208); anti-Ku70 (ab2172); Santa Cruz Biotechnology: anti-Oct-3/4 (sc-5279), anti-SOX2

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Anti-Progerin antibody [13A4] from Abcam

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Anti-Progerin antibody [13A4] from Abcam

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