Fig 1: Reduced APP proteolytic processing in APP/PS1/FTnKO mice. A, B Immunoblots and densitometric analysis of full-length APP (FL-APP), and APP cleavage products, carboxyl-terminal fragments (CTFα and CTFβ), amino-terminal fragments of APP (sAPPα and sAPPβ), and β-secretase 1 (BACE1). Protein levels were normalized by the amount of tubulin with the levels in the APP/PS1 control group set as 100%. C, D Immunoblots and densitometric analysis of proteins involved in Aβ clearance pathways including APOE, LRP1, IDE, and neprilysin. Protein levels were normalized by the amount of tubulin or GAPDH, and the levels in the control group set as 100%. n = 8/genotype; Student’s t-test, 2-tailed; #p = 0.08; *p < 0.05