Fig 2: Heatmap of exosomal proteome abundance changes in disease. Heatmaps were constructed for the significantly different proteins identified in exosomes of Controls vs AD cases, isolated from serum samples of the UA-Cohort. Differences were determined using Welch’s t-test and a 95% confidence level was considered. The bars on the top of heatmaps show the kits category. Red represents higher abundance and light yellow represents lower abundance levels. Abbreviations: AACT, a-1-antichymotrypsin; APOC3, apolipoprotein C-III; APOH, beta-2-glycoprotein 1; C4BPA, C4b-binding protein alpha chain; CO3, complement C3; CO9, complement component 9; Disease, Alzheimer’s disease cases; IGHM, immunoglobulin heavy constant mu; K2C6A, keratin, type II cytoskeletal 6A; KV230, Immunoglobulin kappa variable 2–30