Fig 1: Expression of select surfaceome proteins from top quartile of gene expression. (A) Primary PSCCs (n = 12) were stained for BSG/CD147 (left), FGFR1 (middle), and SLC16A1/MCT1 (right) proteins; top row demonstrates representative staining patterns. (B) Magnification (20×; scale bar is 50 μm) of representative sections demonstrating nuclear vs. membrane localization. (C) Percent of cells with protein expression at the plasma membrane vs. the nuclear compartment (see Section 2 for details). Tumor samples were labeled by HPV status (blue circle = HPV-neg; red triangle = HPV-pos).
Fig 2: Overall survival association with select surfaceome gene expression. Target genes (A) BSG/CD147, (B) FGFR1, (C) SLC16A1/MCT1 were dichotomized into high and low by the median gene expression value. Kaplan–Meier estimates are shown with log-rank comparison between groups.
Fig 3: Representative illustration of immunohistochemical evaluation in primary OSCC tissue sample and corresponding lymph node metastasis (LNM) based on EMMPRIN staining. (A) Overview of primary OSCC with individual ROIs. The upper right corner illustrates the transition to adjacent healthy oral mucosa (ROI 1–3). (B) Enlarged view of ROI 2 (OM), (C) ROI 6 = primary OSCC, and (D) ROI 9 = invasive front (IF). (E) Enlarged view of LNM. Scale bar, 4 mm and 200 μm.
Supplier Page from Abcam for Anti-CD147 antibody [8D6]