Fig 1: Biological relevance of mutations in classical cadherin genes in skin cutaneous melanoma. (A) Lollipop plots of mutations in classical cadherin genes in skin cutaneous melanoma were presented by using NGS data from TCGA cohort (n = 448) (left) and the non-TCGA cohort (n = 396) (right). The non-TCGA cohort includes patients from Broad/Dana Farber (n = 26, Nature 2012), MSKCC (n = 64, NEJM 2014), Broad (n = 121, Cell 2012), Yale (n = 147, Nat Genet 2012), and UCLA (n = 38, Cell 2016). (B) Mutations in the intracellular domains of top-five cadherin genes were compared with mutations in CTNNB1. (C) Co-occurrence analysis among top-four type-II classical cadherin genes (core CDHs) including CDH6, CDH9, CDH10, and CDH18. (D) Gene expression levels of core CDHs during melanoma malignant transition from normal neural crest cells and melanocytes to melanoma. Gene expression data were extracted from the GEO dataset (GDS1965). (E) Physical interactions (heterophilic/homophilic) among the top-four core CDHs were previously characterized and confirmed 35.
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