Acetyl-alpha-Tubulin (Lys40) Antibody 3971S from Cell Signaling Technology

Product Specs
ItemAcetyl-alpha-Tubulin (Lys40) Antibody
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number3971S
Quantity100 µl
ApplicationsW
ReactivityH, M, R
Targettubulin alpha (Lys40) acetylate
Modificationstubulin alpha (Lys40) acetylate
HostRabbit
NCBI Gene AliasesK-ALPHA-1
NCBI Full Gene Nametubulin alpha 1b
ClonalityPolyclonal
Research AreaCytoskeletal Signaling
Molecular Weight52

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Microtubule-Targeting Combined with HDAC Inhibition Is a Novel Therapeutic Strategy for Diffuse Intrinsic Pontine GliomasMolecular Cancer TherapeuticsDecember 1, 2023Anahid Ehteda, Aaminah Khan, Gayathiri Rajakumar, Anne S. Vanniasinghe, Anjana Gopalakrishnan, Jie Liu, Maria Tsoli, David S. Ziegler(1:1,000; Cell Signaling Technology, #8173), acetyl-α-tubulin (1:1,000; Cell Signaling Technology, #3971), HDAC6 (1:1,000; Cell Signaling Technology, #7558)]. Membranes were then washed 5× using PBST and incubated

(2) EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centrioleEMBO reportsJune 5, 2023Xie S, Naslavsky N, Caplan S.(G2000, cat. no. 5213; Cell Signaling Technology), rabbit anti‐human acetylated tubulin (K40, cat. no. 3971; Cell Signaling Technology), rabbit anti‐human Cullin3 (cat. no. 2759; Cell Signaling Technology), mouse

(3) Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesisScience advancesMay 3, 2023Izzo LT, Trefely S, Demetriadou C, Drummond JM, Mizukami T, Kuprasertkul N, Farria AT, Nguyen PTT, Murali N, Reich L, et al.PDHe1α (Santa Cruz Biotechnology, sc-377092), pan-acetyl-lysine (CST, #9441), acetyl-tubulin (CST, #3971), acetyl-H3K23 (CST, #14932), acetyl-H4 (Millipore, 06-866), acetyl-H3K27 (Abcam, ab4729), acetyl-H3K9

(4) Novel dual LSD1/HDAC6 inhibitor for the treatment of cancerPLOS ONEJanuary 3, 2023Chandru Gajendran, Subramanyam Janardhan Tantry, Naveen Sadhu M., Zainuddin Mohammed, Purushottam Dewang, Mahanandeesha Hallur, Sreekala Nair, Krishnakumar Vaithilingam, Basavaprabhu Nagayya, Sridharan Rajagopal, et al.Antibodies were obtained from the following sources: Acetyl-α- Tubulin (Cell Signalling Technology, 3971S, 1:500), β-actin (Santa Cruz Biotechnology, sc47778, 1:2000), HRP-conjugated secondary antibodies (Santa

(5) Combination of Paclitaxel and PXR Antagonist SPA70 Reverses Paclitaxel-Resistant Non-Small Cell Lung CancerCellsOctober 1, 2022Xiaxia Niu, Ting Wu, Qishuang Yin, Xinsheng Gu, Gege Li, Changlong Zhou, Mei Ma, Li Su, Shu Tang, Yanan Tian, et al.1:1000), acetylated lysine (Cell Signaling, #9441, 1:1000), and Acetyl-α-Tubulin (Lys40) (Cell Signaling, #3971, 1:1000). For GST-pulldown assays, IPTG-induced GST or GST fusion proteins were incubated with in vitro

(6) Ciliogenesis requires sphingolipid-dependent membrane and axoneme interactionProceedings of the National Academy of SciencesAugust 2, 2022Dou Wu, Jingying Huang, Hao Zhu, Zhe Chen, Yongping Chai, Jingyi Ke, Kexin Lei, Zhao Peng, Ranhao Zhang, Xueming Li, et al.on the standard protocol using the following primary antibodies: antiacetylated α-tubulin antibody (3971, Cell Signaling Technology, 1:500 dilution), anticeramide antibody (C8104, Sigma, 1:100 dilution). The

(7) NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injuryFrontiers in physiologyJanuary 1, 2022Zemskov EA, Gross CM, Aggarwal S, Zemskova MA, Wu X, Gu C, Wang T, Tang H, Black SM.anti-acetyl-Lys310 NF-κB p65 (Cat # 12629) and the rabbit polyclonal anti-acetyl-Lys40 a-tubulin antibody (Cat # 3971) were from Cell Signaling (Danvers, MA). The mouse monoclonal anti-β-actin antibody (Cat # A3854) and

(8) Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma CellsFrontiers in oncologyJanuary 1, 2021Yan X, Qu X, Liu B, Zhao Y, Xu L, Yu S, Wang J, Wang L, Su J.(Proteintech, Chicago, IL, USA); anti-Acetyl-β-Catenin (Lys49) #9534, anti-acetyl-α-Tubulin (Lys40) #3971 (Cell Signaling Technology, Beverly, Massachusetts, USA). Cell Culture and Transfection SNU-387 and

(9) Thermosensitive bFGF-Modified Hydrogel with Dental Pulp Stem Cells on Neuroinflammation of Spinal Cord InjuryACS omegaJuly 7, 2020Albashari A, He Y, Zhang Y, Ali J, Lin F, Zheng Z, Zhang K, Cao Y, Xu C, Luo L, et al.(ab6671, Abcam), IL-6 (21865-1-AP, Proteintech), NF-κB (8242S, CST), IκB-α (4814, CST), acetyl-α-tubulin (3971S, CST), and MAP-2 (Sigma-Aldrich). Then, the samples were treated with secondary antibodies for another

(10) Role of Ca²⁺ transients at the node of the mouse embryo in breaking of left-right symmetryScience advancesJuly 1, 2020Mizuno K, Shiozawa K, Katoh TA, Minegishi K, Ide T, Ikawa Y, Nishimura H, Takaoka K, Itabashi T, Iwane AH, et al.those to parvalbumin (1:200 dilution; MAB1572, Merck), to acetylated tubulin (1:200 dilution; rabbit: #3971S, Cell Signaling Technology; mouse: T6793, Sigma), to PDI (1:500 dilution; 11245-1-AP, Proteintech),

(11) Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancerScientific reportsFebruary 26, 2020Moufarrij S, Srivastava A, Gomez S, Hadley M, Palmer E, Austin PT, Chisholm S, Roche K, Yu A, Li J, et al.2062), HDAC2 (Cell Signaling, 2540), HDAC6 (Assay Biotech, C0026), acetyl-alpha Tubulin (Cell Signaling, 3971), alpha-Tubulin (Cell Signaling, 3873). RNA extraction and analysis Cells were cultured in T75 dishes

(12) Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cellsScientific reportsApril 16, 2019Knox T, Sahakian E, Banik D, Hadley M, Palmer E, Noonepalle S, Kim J, Powers J, Gracia-Hernandez M, Oliveira V, et al.ICOS-L (Abcam, ab138354), alpha-Tubulin (Cell Signaling, 3873) and acetyl-alpha Tubulin (Cell Signaling, 3971). Statistical Analysis and reproducibility All experiments were done in triplicate unless otherwise

(13) GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functionsMolecular NeurodegenerationDecember 1, 2018Huazhang Zhu, Weizhen Zhang, Yingying Zhao, Xingsheng Shu, Wencong Wang, Dandan Wang, Yangfan Yang, Zhijun He, Xiaomei Wang, Ying YingAntibody,Host,Application,Source,Cat. No β-tubulin,Rabbit,WB(1:1000),CSTa,#2146 Ac-Tubulin,Rabbit,WB(1:1000)/IHC(1:100),CST,#3971 Akt(pan),Rabbit,WB(1:1000),CST,#4691 pS473-Akt,Rabbit,WB(1:1000),CST,#4060 Cleaved caspase-3,Rabbit,WB(1:1000),CST,#9664 Complex

(14) Solute carrier family 35 member F2 is indispensable for papillary thyroid carcinoma progression through activation of transforming growth factor-β type I receptor/apoptosis signal-regulating kinase 1/mitogen-activated protein kinase signaling axisCancer ScienceMarch 1, 2018Jing He et al.

(15) Tubastatin A prevents hemorrhage-induced endothelial barrier dysfunctionJournal of Trauma and Acute Care SurgeryFebruary 1, 2018Peter J. Bruhn, Vahagn C. Nikolian, Ihab Halaweish, Zhigang Chang, Martin Sillesen, Baoling Liu, Yongqing Li, Hasan B. Alambicinchoninic acid method. Proteins were detected using antibodies against acetylated α-tubulin (Lys40, #3971, Cell Signaling Technology Inc., Danvers, MA), and HIF-1α (HIF-1α, #3716, Cell Signaling Technologies

(16) Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapyOncotargetSeptember 15, 2017Hay JF, Lappin K, Liberante F, Kettyle LM, Matchett KB, Thompson A, Mills KI.Cell Signalling, Leiden, NL), H3K9Ac (#9649; Cell Signalling, Leiden, NL) and acetylated α-tubulin (#3971; Cell Signalling, Leiden, NL) monoclonal antibodies were used in conjunction with a horseradish peroxidase

(17) HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastomaCancer lettersAugust 28, 2016Wang Z, Hu P, Tang F, Lian H, Chen X, Zhang Y, He X, Liu W, Xie C.

(18) Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramideMolecular biology of the cellJune 1, 2014He Q, Wang G, Wakade S, Dasgupta S, Dinkins M, Kong JN, Spassieva SD, Bieberich E.(2914S), anti-phospho-PKCζ/λ (Thr-410/403) rabbit IgG (9378P), and anti-acetylated tubulin rabbit IgG (3971) were from Cell Signaling Technology (Danvers, MA). Anti-PKCζ rabbit IgG (serum, P-0713), anti–AurA

(19) HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophyJournal of Cell ScienceApril 1, 2014Adam W. Beharry, Pooja B. Sandesara, Brandon M. Roberts, Leonardo F. Ferreira, Sarah M. Senf, Andrew R. Judgeagainst acetyl-histone H3 (no. 9677, Cell Signaling Technology, Boston, MA); acetyl-a-tubulin (no. 3971, Cell Signaling Journal of Cell Science (2014) 127, 1441–1453 doi:10.1242/jcs.136390 Technology);

(20) Correction: Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia CellsPLoS ONENovember 6, 2013Yoshitaka Sunami, Marito Araki, Yumi Hironaka, Soji Morishita, Masaki Kobayashi, Ei Leen Liew, Yoko Edahiro, Miyuki Tsutsui, Akimichi Ohsaka, Norio Komatsu(Cell Signaling #2525), anti-p53 (Cell Signaling #9252), anti-acetyl-Lys40a-tubulin (Cell Signaling #3971), anti-tubulin (Sigma-Aldrich #T5168), anti-SIRT1 (Sigma-Aldrich #S5322), anti-SIRT2 (Abgent #AJ1718a;

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Acetyl-alpha-Tubulin (Lys40) Antibody

Acetyl-alpha-Tubulin (Lys40) Antibody from Cell Signaling Technology

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Cell Signaling Technology

Citations (23)

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Acetyl-alpha-Tubulin (Lys40) Antibody from Cell Signaling Technology

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