Anti-CDKN2A/p16INK4a antibody [EP435Y-129R] ab81278 from Abcam

Product Specs
ItemAnti-CDKN2A/p16INK4a antibody [EP435Y-129R]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab81278
Antibody TypePrimary
ApplicationsFlow Cytometry, Immunocytochemistry/ Immunofluorescence, Western blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Western blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Western blot
HostRabbit
Conjugate/TagUnconjugated
CloneEP435Y-129R
IsotypeIgG
Quantity10 UL, 40 UL, 100 UL
ClonalityMonoclonal
Concentration0.109 mg/ml
Research AreaEpigenetics
Gene NameCDKN2A
ReactivityHuman
TargetCDKN2A/p16INK4a

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United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Exosomes derived from human dermal fibroblasts protect against UVB‑induced skin photoagingInternational Journal of Molecular MedicineOctober 27, 2023A Yeon Park, Jung Ok Lee, Youna Jang, Yu-Jin Kim, Jung Min Lee, Su-Young Kim, Beom Joon Kim, Kwang Ho YooInc.","1:1,000" Anti-MMP1,PA5-27210,"Thermo Fisher Scientific, Inc.","1:5,000" Anti-p53,ab131442,Abcam,"1:1,000" Anti-p16,ab81278,Abcam,"1:1,000" Anti-collagen type I,ab21965,Abcam,"1:1,000" Anti-RAD51,ab176458,Abcam,"1:5,000" ALIX,ab275377,Abcam,"1:1,000" CD63,ab134045,Abcam,"1:1,000" CALNEXIN,Ab22595,Abcam,"1:1,000" Anti-p21,2947s,"Cell Signaling Technology

(2) Vemurafenib induces a noncanonical senescence-associated secretory phenotype in melanoma cells which promotes vemurafenib resistanceHeliyonJuly 3, 2023Jianyu Peng, Zijun Lin, Weichun Chen, Jie Ruan, Fan Deng, Lin Yao, Minla Rao, Xingdong Xiong, Shun Xu, Xiangning Zhang, et al.807/811) (#9308), Cyclin D1 (#55506), Erk1/2 (#9102) and p-Erk1/2 (Thr202/Tyr204) (#9101). The p16INK4a (ab81278) antibody was obtained from Abcam PLC. (Cambridge, UK) and α-tubulin (T5168) was obtained from Sigma-Aldrich

(3) Nintedanib induces senolytic effect via STAT3 inhibitionCell Death & DiseaseSeptember 2, 2022Hyun-Ji Cho, Jeong-A Hwang, Eun Jae Yang, Eok-Cheon Kim, Jae-Ryong Kim, Sung Young Kim, Young Zoon Kim, Sang Chul Park, Young-Sam Leehave been used for immunofluorescence staining: anti-p53 (sc-126, Santa Cruz Biotechnology), anti-p16 (ab81278, Abcam) Senescence-associated β-galactosidase (SAβG) staining A SAβG activity in cells was assessed

(4) Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancerScience advancesMay 13, 2022Stanzione M, Zhong J, Wong E, LaSalle TJ, Wise JF, Simoneau A, Myers DT, Phat S, Sade-Feldman M, Lawrence MS, et al.Cell Signaling Technology), SLFN11 (1:500; sc-374339, Santa Cruz Biotechnology), p57 (1:500; ab75974, Abcam), p16 (1:2000; ab81278, Abcam) and p21 (1:1000; 2947, Cell Signaling Technology), CYCLIN A2 (1:1000; 4656, Cell Signaling Technology),

(5) High expression of NFX1-123 in HPV positive head and neck squamous cell carcinomasHead & neckJanuary 1, 2022Chintala S, Quist KM, Gonzalez-DeWhitt PA, Katzenellenbogen RA.Louis, MO, USA, cat# OP43, 1:1000 dilution); p16 (Rabbit monoclonal, Abcam, Cambridge, MA, USA, cat# ab81278, 1:1000 dilution), KRT16 (Rabbit monoclonal, Abcam, Cambridge, MA, USA, cat# ab76416, 1:500 dilution),

(6) P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7Frontiers in cell and developmental biologyJanuary 1, 2022Li Z, Qiao J, Ma W, Zhou J, Gu L, Deng D, Zhang B.RIPA buffer. The primary polyclonal antibody against P14 (ab3648, Abcam), P15 (ab53034, Abcam), P16 (ab81278, Abcam), CBX7 (ab21873, Abcam), GAPDH (60004-1, ProteinTech), or green fluorescent protein (GFP) (ProteinTech,

(7) Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretionNature CommunicationsDecember 1, 2021Shintaro Okumura et al.performed using the primary antibodies against ɑ-SMA (1:100, Abcam, ab125057) and p16 (1:1000, Abcam, ab81278). For immunofluorescence analysis of murine and human tissues, the secondary antibodies used were as

(8) DIAPH1 Promotes Laryngeal Squamous Cell Carcinoma Progression Through Cell Cycle RegulationFrontiers in OncologySeptember 22, 2021Jiechao Yang, Qiang Huang, Yang Guo, Zheqiang Wei, Liang Zhou, Hui Chen(1:1000, Cell Signaling Technology [CST], USA, cat. no. 3686), anti-p16Ink4a (1:1000, Abcam, cat. no. ab81278), anti- p21Waf1/Cip1 [1:500, Santa Cruz Biotechnology (Santa), USA, cat. no. sc-817], anti-p19Ink4d

(9) Transcriptome Analysis of Large to Giant Congenital Melanocytic Nevus Reveals Cell Cycle Arrest and Immune Evasion: Identifying Potential Targets for TreatmentJournal of immunology researchJanuary 1, 2021Wei B, Gu J, Duan R, Gao B, Wu M, Zhou S, Huang X, Xie F.antibody (ab16667, Abcam, 1 : 200)/anti-SOX10 antibody (GTX35085, GeneTex, 1 : 100) or anti-P16 antibody (ab81278, Abcam, 1 : 200)/anti-SOX10 antibody, followed by further incubation at 20–30°C for 1 h with goat anti-rabbit IgG H&L (FITC

(10) Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like responseBiology OpenMay 16, 2019Geng-You Liao, Ming-Ting Lee, Jhen-Jia Fan, Pei-Wen Hsiao, Chun-Sheng Lee, Shou-Yi Su, Jiuan-Jiuan Hwang, Ferng-Chun Kep53 (#DO1), p21CIP1 (#F5) and p16INK4A (#H156) were from Santa Cruz Biotechnology; another anti-p16 (ab81278) and anti-H3K9Me3 (ab8898) antibodies were from Abcam (Cambridge, UK); anti-β-actin was from Sigma-Aldrich;

(11) The anti-tumor efficacy of CDK4/6 inhibition is enhanced by the combination with PI3K/AKT/mTOR inhibitors through impairment of glucose metabolism in TNBC cellsJournal of Experimental & Clinical Cancer ResearchDecember 1, 2018Daniele Cretella et al.anti-p-CDK6Tyr24 (sc-293,097) was from Santa Cruz Biotechnology, Incorporated (Dallas, TX). Anti CDKN2A/p16INK4a (ab81278) and anti-GLUT-1 (ab40084) were from Abcam (Cambridge, UK). Antibody against HIF-1α (#610959) was from

(12) Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cellsCytotechnologyDecember 1, 2018Gakuro Harada, Shiori Onoue, Chisato Inoue, Sakae Hanada, Yoshinori Katakuraincubated overnight at 4 °C with anti-phospho-p38 (#4511, Cell Signaling, Beverly, MA, USA); anti-p16 (ab81278; Abcam, Cambridge, MA, USA); anti-phospho-histone H2A.X (#9718, Cell Signaling) antibodies. Cells were

(13) The induction of the fibroblast extracellular senescence metabolome is a dynamic processScientific ReportsDecember 1, 2018Emma N. L. James, Mark H. Bennett, E. Kenneth Parkinsonas described previously51 using the following antibodies: p16INK4A (Anti-CDKN2A/p16INK4a EP4353Y(3) ab81278 from Abcam, UK), MCM7 (Anti-MCM7 EP1974Y ab52489 from Abcam, UK) and β-actin. All antibodies were diluted

(14) Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461Journal of Experimental & Clinical Cancer ResearchDecember 1, 2018Guihong Li et al.(Cell Signaling Technology, #2978, diluted 1:1000), p53 (Cell Signaling Technology, #2527, diluted 1:1000), p16 (Abcam, ab81278, diluted 1:2000), γ-H2AX (Abcam, ab81299, diluted 1:5000), 53BP1 (Abcam, ab175933, diluted 1:5000),

(15) Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemiaNature CommunicationsDecember 1, 2018Carmen D. Herling et al.in tris-buffered saline for 1 h. Blots were probed with the following antibodies against: CDKN2A (#ab81278, Abcam, Cambridge, UK, 1:1000), BRAF (sc-5285, Santa Cruz, 1:500), and MCL1 (CST-5453, Cell Signaling,

(16) Chronic p27^Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid ReceptorScientific reportsOctober 30, 2018Patki M, McFall T, Rosati R, Huang Y, Malysa A, Polin L, Fielder A, Wilson MR, Lonardo F, Back J, et al.FOXO4 (#55D4) antibodies were purchased from Cell Signaling Technology, Danvers, MA. Anti-p16INK4a (#ab81278) was from Abcam. Anti-α-tubulin (sc-8035) and GAPDH (sc-47724) antibodies were purchased from Santa Cruz Biotechnology

(17) CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repairCell Death & DiseaseAugust 30, 2018Yuzhen Zhou, Li Chu, Qi Wang, Weixing Dai, Xiaozhou Zhang, Jianfeng Chen, Ling Li, Peipei Ding, Long Zhang, Hongyu Gu, Luying Li, Xinyue Lv, Wei Zhang, Danlei Zhou, Pingzhao Zhang, Guoxiang Cai, Kuaile Zhao, Weiguo Hu(sc-245, Santa Cruz), γH2AX (Ser139) (ab22551, Abcam), NBS1 (#3002, Cell Signaling Technology), p16 (ab81278, Abcam), p21 (ab109199, Abcam), and β-actin (sc-7963, Santa Cruz). Survival fraction A LQ model was

(18) Role of accelerated aging in limb muscle wasting of patients with COPDInternational Journal of Chronic Obstructive Pulmonary DiseaseJuly 5, 2018Ramzi Lakhdar, Dagmara McGuinness, Ellen M Drost, Paul G Shiels, Ricardo Bastos, William MacNee, Roberto A Rabinovich

(19) Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytesCytotechnologyJune 1, 2018Zhao Chong, Haruka Matsuo, Mai Kuroda, Shuntaro Yamashita, Gopal Prasad Parajuli, Hira Kaji Manandhar, Kuniyoshi Shimizu, Yoshinori Katakurablocked with 5% goat serum and 0.3% Triton-X100. After washing the cells, specific antibodies (anti-p16INK4a (ab81278, Abcam, Cambridge, UK), anti-p21 (2947, Cell Signaling, Danvers, MA, USA), anti-phospho p38 (4511, Cell Signaling

(20) Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathwayCell death & diseaseFebruary 15, 2018Sun X, Shi B, Zheng H, Min L, Yang J, Li X, Liao X, Huang W, Zhang M, Xu S, et al.Waf1/Cip1 (#2946), p-Rb (Ser807/811) (#9308), IκBα (#4812) and FRA1 (#5281). The antibodies of p16INK4a (ab81278) and DDB2 (ab181136) were obtained from Abcam PLC. (Cambridge, UK). Anti-IL-8 (MAB208), anti-IL-1α (MAB200)

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Anti-CDKN2A/p16INK4a antibody [EP435Y-129R] from Abcam

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Anti-CDKN2A/p16INK4a antibody [EP435Y-129R] from Abcam

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