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Antibodies
Anti-KMT4 / Dot1L antibody
Anti-KMT4 / Dot1L antibody from Abcam
Be the first to write a review!
Citations:
(17)
Supplier Page
Supplier Page from
Abcam for
Anti-KMT4 / Dot1L antibody
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Anti-KMT4 / Dot1L antibody
Company
Abcam
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
ab64077
Antibody Type
Primary
Quantity
100 UG
Applications
Immunocytochemistry/ Immunofluorescence, Western blot
Conjugate/Tag
Unconjugated
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Concentration
0.9 mg/ml
Research Area
Epigenetics
Gene Name
DOT1L
Reactivity
Human, Mouse
Target
KMT4 / Dot1L
Add to Compare List
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB2 0AX
United Kingdom
Phone
: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600
Company Profile
Website:
http://www.abcam.com
Citations (17)
(1)
Aldosterone inhibits Dot1l expression in guinea pig cochlea
European Journal of Medical Research
January 13, 2023
Shixun Zhong, Biyun Zhang, Li Qin, Qianying Wang, Xiaoli Luo
temperature. Subsequently, the sections were orderly incubated with rabbit anti-Dot1l antibody (
1:100
,
ab64077
,
Abcam
, UK) overnight at 4 ℃, biotin labeled goat anti-rabbit IgG and SABC for 30 min at 37 ℃, respectively.
(2)
Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma
Journal of Pharmaceutical Analysis
January 1, 2023
Xiang Gu, Yu Hua, Jie Yu, Ludi Yang, Shengfang Ge, Renbing Jia, Peiwei Chai, Ai Zhuang, Xianqun Fan
(
ZEISS
Axio Scope A1
, Oberkochen, Germany). The primary antibodies used in the
assay
were anti-DOT1L (
ab64077
,
Abcam
, Waltham, MA, USA,
1:200
), anti-H3K79me2 (
ab3594
,
Abcam
,
1:500
), and anti-NAPRT (
13549-1-AP
,
(3)
Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis
JCI Insight
December 22, 2021
Astrid De Roover, Ana Escribano Escribano Núñez, Frederique M.F. Cornelis, Chahrazad Cherifi, Leire Casas-Fraile, An Sermon, Frederic Cailotto, Rik J. Lories, Silvia Monteagudo
serum for 30 minutes, and incubated overnight at 4°C with primary antibodies against
DOT1L
(
Abcam
,
ab64077
, 6 μg/ml) or
HIF1A
(Abcam,
ab82832
, 10 μg/ml) or for 90 minutes with primary antibody against H3K79me2
(4)
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons
Nature neuroscience
May 1, 2021
Kronman H, Torres-Berrío A, Sidoli S, Issler O, Godino A, Ramakrishnan A, Mews P, Lardner CK, Parise EM, Walker DM,
et al
.
membranes
were incubated in primary antibody in blocking solution overnight at 4°C (
Dot1l
,
Abcam
, cat #
ab64077
; Actin, MP Biomedical, cat #691001). Following multiple washes,
membranes
were incubated in peroxidase-based
(5)
Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress
Oxidative Medicine and Cellular Longevity
February 15, 2021
Shanshan Wan, Yiwen Zhou, Qiong Huang, Yanning Yang
polyacrylamide gel electrophoresis
gels and then transferred to a nitrocellulose
membrane
. Primary antibodies against Dot1l (
ab64077
), catalase (
ab209211
), SOD1 (
ab51254
), SOD2 (
ab68155
),
p38
(
ab31828
), p-
p38
(
ab178867
), and β-actin
(6)
Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator
Cell reports
June 23, 2020
Mizrak D, Bayin NS, Yuan J, Liu Z, Suciu RM, Niphakis MJ, Ngo N, Lum KM, Cravatt BF, Joyner AL,
et al
.
monoclonal anti-PVALB,
Millipore Sigma
,Cat#
mab1572
; RRID: AB_2174013 Rabbit polyclonal anti-DOT1L,
Abcam
,Cat#
ab64077
; RRID: AB_2095412
Mouse
monoclonal anti-RELN,
Millipore Sigma
,Cat#
mab5364
; RRID: AB_2179313 Rabbit
(7)
Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer
Clinical epigenetics
December 30, 2019
Yang L, Lei Q, Li L, Yang J, Dong Z, Cui H.
Western blot Western blot
was performed as previously described [40]. The antibodies used were listed as below: DOT1L (
ab64077
,
Abcam
),
CDK2
(
2546
,
CST
), Cyclin A2 (
4656
,
CST
),
PCNA
(
13110
,
CST
),
GAPDH
(
51332
,
CST
),
c-Myc
(
5605
,
(8)
Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression
Stem Cells
May 1, 2019
Giannios I, Serafimidis I, Anastasiou V, Pezzolla D, Lesche M, Andree C, Bickle M, Gavalas A.
antibodies used were: rabbit anti‐Prmt1 (
1:1,000
, 2,449, Cell Signaling), rabbit anti‐Dot1l (2.5 μg/ml,
AB64077
,
Abcam
), mouse anti‐Setd7 (
1:500
,
AB14820
,
Abcam
) and
mouse
anti‐β‐actin (
1:10,000
,
MAB1501
,
Sigma
).
(9)
SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation
Cell Death & Differentiation
June 1, 2017
Charlotte Moretti et al.
(10)
Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer
Journal of hematology & oncology
January 23, 2017
Zhang X, Liu D, Li M, Cao C, Wan D, Xi B, Li W, Tan J, Wang J, Wu Z,
et al
.
(ABC) Vectastain Kit (Zsgb-Bio, Beijing, China) was used and the DOT1L polyclonal antibody (
1:250
;
ab64077
;
Abcam
), H3K79me2 polyclonal antibody (
1:200
;
ab3594
;
Abcam
), cyclin D3 antibody (
1:100
;
ab63535
;
Abcam
),
(11)
Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma
Oncotarget
December 20, 2016
Yang Qu, Li Liu, Jiajun Wang, Wei Xi, Yu Xia, Qi Bai, Ying Xiong, Qilai Long, Jiejie Xu, Jianming Guo
evaluation
Immunohistochemical staining
was performed on tissue
microarray
(TMA) with antibody against Dot1l (
ab64077
,
Abcam
,
1:100
dilution) and proper visualization reagent (DakoEnVision Detection System) as previously
(12)
The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism
Oncotarget
June 7, 2016
Alessa Kühn, Denise Löscher, Rolf Marschalek
kDa,
ab38295
,
Abcam
), CDK9 (43 kDa,
sc-484
,
Santa Cruz
), CYP33 (33 kDa, Abcam), DOT1L/KMT4 (171 kDa,
ab64077
,
Abcam
), IRX1 (50 kDa,
ab72642
, Abcam), LEDGF (60-68 kDa,
ab49281
,
Abcam
), mCherry (
MLL
-AF4-mCH, 260
(13)
DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression
Nature communications
July 22, 2015
Cho MH, Park JH, Choi HJ, Park MK, Won HY, Park YJ, Lee CH, Oh SH, Song YS, Kim HS,
et al
.
cut from each tissue
microarray
(TMA) block and immunostained with antibodies to DOT1L (
1:200
,
Abcam
,
ab64077
, Cambridge, MA, USA) using the Bond-Max autostainer (Leica, Wetzlar, Germany). Each core was evaluated
(14)
H3K79 methylation directly precedes the histone-to-protamine transition in mammalian spermatids and is sensitive to bacterial infections
Andrology
September 1, 2014
C Dottermusch-Heidel, E S Klaus, N H Gonzalez, S Bhushan, A Meinhardt, M Bergmann, R Renkawitz-Pohl, C Rathke, K Steger
(15)
Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes
Chromosoma
March 1, 2014
David Ontoso, Liisa Kauppi, Scott Keeney, Pedro A. San-Segundo
(16)
Involvement of DOT1L in the remodeling of heterochromatin configuration during early preimplantation development in mice
Biology of reproduction
December 1, 2013
Masatoshi Ooga, Masataka G Suzuki, Fugaku Aoki
(17)
Genome-wide association and functional studies identify the
DOT1L
gene to be involved in cartilage thickness and hip osteoarthritis
Proceedings of the National Academy of Sciences
May 22, 2012
Martha C. Castaño Betancourt et al.
adult knee sections and nondecalcified embryonal sections was performed with rabbit anti-DOT1L antibody (
Ab64077
;
Abcam
) (5 μg/mL). After overnight
incubation
of the sections at 4 °C,
1:100
peroxidase goat anti-rabbit
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Anti-KMT4 / Dot1L antibody from Abcam
Supplier Page
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Pricing Info
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