Fig 1: T2DM-stroke induces liver immune-response earlier and stronger than in other peripheral organs. (A,B) Western blot was used to measure the expression of inflammatory factors, cytokines, and acute phase response related proteins at 1 and 3 days after stroke in T2DM mice. Stroke in T2DM mice induces earlier and higher cytokine and acute phase response protein expression such as SAA, NLRP3, IL1ß, IL6, TNFa and TLR4 in the liver compared to heart and kidney. The bands correspond to the precursor form for IL1ß and TNFa. n = 3/group.