Fig 1: Effects of Aß1-6A2V(D) on synaptic integrity.Biochemical study on APPSwe/PS1dE9 mice intranasally treated with Aß1-6A2V(D) every 48 h for 5 months. The levels of the synaptic proteins NR2A, NR2B, GluA1, GluA2 and PSD-95 were analyzed by western blot. Two representative animals from each group are included in the figure. The densitometric analysis showed a significant increase in the levels of GluA1 (*p = 0.015) and GluA2 (**p = 0.007) and a trend toward an increase in the levels of NR2A, NR2B and PSD-95 in mice treated with Aß1-6A2V(D) (red columns, n = 10) compared to animals treated with saline solution (blue columns, control group, n = 10).