Description
Product Characteristics:
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular location: Cytoplasm, Nucleus
Synonyms: CAP E, CAPE, Chromosome associated protein E, Chromosome-associated protein E, FLJ10093, hCAP E, hCAP-E, hCAPE, PRO0324, SMC 2, SMC protein 2, SMC-2, SMC2, SMC2 L1, SMC2_HUMAN, SMC2L1, Structural maintenance of chromosomes SMC family member chromosome associated protein E, Structural maintenance of chromosomes 2, Structural maintenance of chromosomes 2 like 1, Structural maintenance of chromosomes 2 yeast like 1, Structural maintenance of chromosomes protein 2, XCAP E homolog, XCAP-E homolog, XCAPE homolog.
Target Information: Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A\, MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]