Fig 1: Expression of TAP-2 protein in cervical tissues stratified according to the severity of the lesion.Legend: Immunohistochemical staining with anti-TAP-2 (left images) in cervical biopsy specimens with a benign lesion (A), CIN 1 (B), CIN 2 (C), and CIN 3 (D). Labeling intensity progressively increases from mild to strong according to the severity of the cervical lesion. H&E staining (right images) cervical biopsy specimens with a benign lesion (E), CIN 1 (F), CIN 2 (G), and CIN 3 (H). Magnification ×400.
Fig 2: Gene and protein expression of TAP2 stratified according to the TAP2 gene diplotypes. Number of patients evaluated (N). TAP2B/TAP2B (B/B); TAP2A/TAP2A (A/A); TAP2A/TAP2D (A/D); TAP2A/TAP2C (A/C). Evaluation of TAP2 expression in mRNA (A, C) and protein (B, D). Presence of HPV infection (HPV+). Absence of HPV infection (HPV-). The Mann-Whitney or Kruskal-Wallis tests were used to estimate the differences between the TAP-2 expressions in the evaluated groups.
Fig 3: TAP-2 protein levels and TAP2 gene expression, stratified according to the severity of the cervical lesions, the chromosomal number, and the HPV infection.Legend: Number of patients analyzed (N). Note: The Mann-Whitney or Kruskal-Wallis tests were used to estimate the differences between the expressions of TAP-2 protein and TAP2 mRNA in the evaluated groups. TAP-2 protein expression (A–C) in cervical biopsy samples and TAP2 gene expression (D–F) in cervical exfoliative samples.
Fig 4: Evaluation of TAP2 genotypes according to gene and protein expression stratified by HPV infection.Legend: Number of patients analyzed (N). Presence of HPV infection (HPV+). Absence of HPV infection (HPV-). Note: The Mann-Whitney test was used to estimate the differences between the expressions of TAP-2 protein in cervical biopsy samples (A–D) and TAP2 mRNA in cervical exfoliative samples (E–H).
Fig 5: Gene and protein expression of TAP2 stratified by TAP2 gene haplotypes.Legend: Number of haplotypes observed (N). Note: The Mann-Whitney test was used to estimate the differences between the expressions of TAP-2 protein in cervical biopsy samples (A, B) and TAP2 mRNA in cervical exfoliative samples (C, D).
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