Fig 1: Expression of phototransduction protein and IPM protein in ISL1-/- hESC-derived photoreceptors after transplantation(A) Summary of phototransduction signaling cascades.(B) Expression of rod phototransduction proteins (a–g), cone phototransduction proteins (h–m), and guanylyl cyclase (GC) and GC-activating proteins (n–q) in the Crx::Venus+ photoreceptor rosettes. Maturation of photoreceptors with IS/OS formation was indicated by PRPH2 (r). Expression of IPM proteins was found in the rosette (s–x).(C and D) Expression of IRBP, IMPG1(C), and GNAT1 (D) in the ISL1-/- hESC graft.