Fig 2: Effect of tumor size, histologic grade, FOSL1 expression and tumor recurrence on OS. Kaplan-Meier survival curves for the cumulative (cum) OS according to the log rank test. The OS rate of the HCC patients with tumor size > 5 cm (red line) was significantly lower than that of the patients with tumor size < 5 cm (blue line) (a). The OS rate of the HCC patients with histological grade II and III (red and green lines) were significantly lower than that of the patients with histological grade I (blue line) (b). The OS rate of the HCC patients with strong FOSL1 expression (red line) was significantly lower than that of the patients with moderate or weak FOSL1 expression (green and blue line) (c). The OS rate of the HCC patients with recurrence (red line) and with no recurrence (blue line) (d). FOSL1: FOS-like antigen 1; HCC: hepatocellular carcinoma; OS: overall survival.

Fig 3: Immunohistochemical staining of FOSL1 in HCC (× 400), showed combined weak cytoplasmic and moderate nuclear expression for FOSL1 (a), combined moderate cytoplasmic and strong nuclear expression (b), combined moderate cytoplasmic and weak nuclear expression (c), and combined strong cytoplasmic expression and strong nuclear expression for FOSL1 (d). FOSL1: FOS-like antigen 1; HCC: hepatocellular carcinoma.

Fig 4: Immunohistochemical staining of FOSL1 in HCC tumor tissues (× 400) showed weak nuclear expression for FOSL1 (a), moderate nuclear expression (b), strong nuclear expression for FOSL1 (c), weak cytoplasmic expression for FOSL1 (d), moderate cytoplasmic expression (e), and strong cytoplasmic expression for FOSL1 (f). FOSL1: FOS-like antigen 1; HCC: hepatocellular carcinoma.